Abstract: Photodynamic treating tumors focuses on people′s superficial tissue region due to the lack of laser light penetration into tissue. In order to overcome photodynamic treatment limitation, the anti-tumor effect of hematopophyrin derivatives activated by ultrasound (namely: sonodynamic treatment) has been a hot research area which has attracted much attention both home and abroad in recent years. This paper introduces the progress of study ,the research results, the experiment method and the theory of tumor treatment with sonodynamic method. Existing problem of the clinical application and the future development prospect have been discussed.