Abstract: Diamond anvil cell (DAC) experimental technique is widely employed in the fields of physics, chemistry and materials for scientific research. Since Bridgman carried out metal anvil device and later development of DAC technique, novel design of DAC and applied pressure technique have been developed. This paper introduces the piezoelectric driving DAC device for achieving high pressure at low temperature of 20 K by in situ continuous tuning pressure. A tuning range is about 2—4 GPa. The DAC device can be easily embedded in a cryostat due to its small size and convenient operation.