Abstract: Surface plasmon polaritons (SPPs) have extensive application prospects in high-sensitivity biosensing because of their extraordinary optical properties. However, the large size and cost of prism-based plasmonic sensors limit their commercial applications. Fortunately, the emergence of metallic nanostructured sensors has provided an effective approach to realize low-cost and highly integrated plasmonic sensors. In this review, we first assess the current status and advantages of plasmonic nanostructured sensors, then focus on our group's recent research on their miniaturization, integration, and fabrication cost reduction. Our work is of significance for the development of both plasmonic sensing theory and nanostructured sensing technology.