Abstract: This article reviews Mrs. Ho Zah-Wei's academic experiences in several different aspects. She inherited the idea of "Saving the Nation by Science" from older scholars such as Cai Yuanpei. Receiving advanced scientific education and discipline, she made the important innovation through international communication and collaboration. After returned to China, She took part in the foundation of the Chinese nuclear science, assembled and trained many prominent scientists.To commemorate her centennial, we should not only cherish her scientific innovation and undertaking, but also develop her scientific spirit and tradition.